Parkinson’s Foundation Global Genetics Study Hits Enrollment Milestone. ![]() Parkinson’s Foundation announces major expansion of PD GENEration study, increasing access to genetic testing and counseling across the US. The role of LRRK2 in neurodegeneration of Parkinson disease. LRRK2 G2019S mutation: frequency and haplotype data in South African Parkinson disease patients. Statement: Biogen Provides Update on Parkinson’s Disease Clinical Development Program. The program seeks to help those with PD, with the results potentially identifying those who could be candidates for clinical trials. 5 Individuals have been enrolled from all 50 US states, Puerto Rico, and the Dominican Republic. The study has an enrollment goal of 15,000 participants-and in March 2023, hit a recruitment milestone of 7500 participants. The program now includes more than 20 actively enrolling participant sites and an effort to expand the reach of new testing sites into historically excluded communities. ![]() In May 2022, the Parkinson’s Foundation announced the expansion of its PD GENEration: Mapping the Future of Parkinson Disease program, which offers no-cost genetic testing for Parkinson-related genes and genetic counseling for participants to better understand their results. There are challenges, though, with identifying candidates for clinical trials of PD with mutations such as these-genetic tests are typically not covered by health insurance, which may lead to a lack of understanding of the presence of possible mutations in genes relevant to the disease, such as LRRK2 or GBA. 2 It has also been reported that dysfunction of LRRK2 may influence the accumulation of alpha-synuclein and its pathology to alter cellular functions and signal pathways by the kinase activation of LRRK2. The accumulation of α-synuclein is one of the main stimulants of microglial activation, which is believed to contribute to neuroinflammation and neuronal death in PD. Those of Ashkenazi Jewish or North American Arab Berber descent experience a higher frequency between 30% and 40% of cases. Mutations in the LRRK2 gene are among of the most common genetic causes of PD, explaining an estimated 4% to 5% of familial and 1% to 2% of sporadic PD cases. To understand whether BIIB122 slows the worsening of symptoms, investigators are evaluating patients on Movement Disorder Society-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) Parts 2 and 3. They are randomly assigned to either 225 mg of oral BIIB122 or placebo once daily for a minimum of 48 weeks and a maximum of 144 weeks. LUMA is a double-blind, placebo-controlled study that aimed to include 640 participants between the ages of 30 and 80 years with early-stage PD. WATCH NOW: Trichloroethylene Exposure and Usage, Environmental Associations in Parkinson Disease: Samuel M. The companies noted in the announcement that the decision was made “in consideration of the LIGHTHOUSE study’s complexity including the long timeline with anticipated study completion in 2031.” They added that the modifications were not because of safety or efficacy data from studies of the treatment and that they “remain committed to advancing the development of BIIB122.” Biogen and Denali noted that those patients who are currently enrolled and randomly assigned in the LIGHTHOUSE study should speak to their physician regarding participation in LUMA or other treatment options. Haeberlein, PhD, the head of Neurodegeneration Development at Biogen, said in a statement that " LRRK2 inhibition may be a promising therapeutic approach to the disease" and that LIGHTHOUSE would have "enabl us to test the genetic hypothesis and implicated lysosomal pathway." The LIGHTHOUSE study was the largest study ever undertaken in individuals with PD caused by an LRKK2 mutation. ![]() No statement was issued by Biogen leadership/ Previously, in October 2022, Samantha B. The companies are choosing to refocus their efforts “to enable a timely readout on efficacy in early-stage idiopathic Parkinson's disease while gaining further clinical data in Parkinson’s disease with and without an LRRK2 mutation.” Those patients with PD related to LRRK2 mutations who were enrolled in the now discontinued program will be offered an opportunity to join the ongoing phase 2b LUMA study (NCT05348785), which began in May 2022. As a result of this decision, the phase 3 LIGHTHOUSE study (NCT05418673), which was initiated in September 2022, will be terminated. Biogen and Denali have announced that they are discontinuing a portion of the clinical development program for BIIB122 (also known as DNL151), an investigational small molecule inhibitor of LRRK2 in development for the treatment of Parkinson disease (PD).
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![]() If you only want one or some of the Creative Cloud apps, there are cheaper options. The month-to-month plan is much more expensive per month but does give you the flexibility to stop and restart your subscription without a cancellation fee. The annual plan is the best value overall, as long as you expect to use the Creative Cloud for a whole year, because you’ll have to commit to 12 months of payments. You have the choice of paying for either annually or monthly. This gives you access to the entire, comprehensive suite of 20+ apps, plus 100GB of cloud storage, the portfolio creation tool Adobe Portfolio and the Adobe Fonts library. ![]() The priciest is a full All Apps subscription which is £51.98 / $54.99 / AU$79.99. There are a few different ways to access the software in the Adobe Creative Cloud. You do need to validate your membership online once every 99 days, but once you do that (and receive your updates), you're actually completely free to use Adobe Creative Cloud completely offline. If you're more traditionally-minded, don't worry - you can also save your work directly to your device of choice as well and work offline. This comes with the added advantage of being able to share your work easily and also collaborate with other subscribers. That said, there are a few exceptions like the Photoshop app for the iPad.Īs with most 'Cloud' services, Adobe CC gives you the ability to backup your work directly to the Adobe network itself. Like a traditional application, you'll have to install it directly onto your devices – preferably a PC or Mac, as some apps aren't supported on Chromebooks or mobile devices. If you're a creative professional, no doubt you've already heard of applications like Photoshop, Illustrator, After Effects, and Premiere Pro – well-renowned programmes that are somewhat of an institution in the design world.Īdobe Creative Cloud: start your free 7-day trialĭespite being labelled as a 'Cloud' service, Adobe CC isn't operated via your web-browser like most other Cloud-related products. Industry-leading tools for graphic design, web design, photography, marketing, and website building can all be at your fingertips with one unified subscription.
![]() Using fashion as a fun way to express her own personal style, Eni has created a platform where she produces stunning visuals and inspiring outfits that are easy for everyone to recreate. ![]() You can find more of Catarina’s content on her blog and Instagram.Įni is a petite fashion blogger based in the UK, originally born in Nigeria, who works as a blogger, YouTuber, and stylist in London. There’s also her Fancy PJs post where she discusses some of the hottest nightwear pieces of the moment that will help you to fall asleep in style. Some of the most popular posts that you will find on Catarina’s blog include her Recommendations post which she frequently updates with the fashion pieces that have recently caught her eye. She’s also about to have a baby, so you’ll be able to find a lot of pregnancy-style tips on her blog. Catarina is a talented photographer that captures her fashion in a moody and artistic style that sets her apart from other bloggers and helped her build a large base of loyal followers.Ĭatarina’s style is very classic and sophisticated with the appearance of a lot of neutral colors in most outfits. Mira-Me is a fashion blog with excellent visuals. ![]() Catarina Mira – Best Photography Fashion BlogĬatarina Mira is a fashion influencer, originally born in Portugal, that made the move over to London to fulfill her creative ambitions and start her blog, Mira-Me. You can find more of Babba’s content on Instagram and Twitter. Some of Babba’s most popular posts include her guide to summer dressing and her more recent tips video that explains how you can easily style loafers. She effortlessly mixes casual outfits with bright colors, statement pieces, and killer accessories that would look great on everyone.Īlongside her fashion content, Babba is also the resident Eco Beauty Expert at Vogue Scandinavia and has gone on to launch her own clean haircare range, inspired by her Latinx heritage, called Ceremonia. If you’re looking for unique street-style inspiration, Babba’s page is the perfect place to look. Babba C Rivera – Best Eco-Conscious Bloggerīabba C Rivera is a Swedish Latina currently living in New York City whose minimal, Scandinavian-inspired style has helped her to gather over 159,000 followers on Instagram alone-she’s so successful that she even found herself on the Forbes Under 30 list! We’re telling you everything you need to know about their fashion sense, the type of content you can expect, and where you can follow them online. Maybe, you’ll find inspiration to start your own blog and you’ll make it to our list one day! Best Fashion Blogs and Bloggers to Follow 2023īelow you’ll find our list of the 30 best fashion blogs and bloggers. Our list covers all of the best fashion content, style advice, and style tips from across the internet.Īfter checking out all of the biggest names in fashion blogging, your wardrobe will be looking better than ever! To help you keep up with the latest fashion trends, we’ve rounded up a list of our favorite blogs and bloggers that we think everyone should be following in 2023. Whether you’re trying to get some back-to-school outfit ideas or need a killer look to wear to the office, fashion blogs and bloggers have become a great source of inspiration. There's absolutely no question who Rosalee will end up with and we've seen all these characters before - the Hollywood star in a small town ("In and Out," "Bye, Bye Birdie") who needs lines written for him, the local (Rosalee's dad Henry) who goes Hollywood in return ("Doc Hollywood"), the guy too shy to vocalize his love and the girl who fails to recognize it, the person who raises the underdog's stock (Fraziers Bottom bartender Angelica) by yearning for him and the completely selfless, supportive best friend. ![]() ![]() When the Levys follow, waving the role he sought before him, Tad asks Rosalee to go back with him to Hollywood. Deciding that he wants some of Rosalee's goodness to 'rub off on him,' Tad descends on the small town of Fraziers Bottom and unknowingly trumps every move Pete makes against him. Of course, Rosalee wins the contest, and her sweet, fresh beauty touches something in Tad. Manager Richard Levy (Sean Hayes, "Pieces of April") and agent Richard Levy (Nathan Lane, currently being heard in "Teacher's Pet") come up with the contest idea to temper Tad's image and snag him a role in a big upcoming film. Tad Hamilton (Josh Duhamel, TV's "Las Vegas" and "All My Children") is a Hollywood bad boy just recently featured on a tabloid cover speeding, drinking, smoking and groping all at the same time. ![]() "Tad Hamilton" is a charming bit of fluff for all ages that should land Topher Grace leading man status. Pete's timing couldn't be worse, though, as Rosalee, smitten with a Hollywood star, has entered a contest to "Win a Date with Tad Hamilton!" Laura: Screenwriter Victor Levin (HBO's "The Larry Sanders Show") trots out every romantic comedy cliche in "Win a Date with Tad Hamilton!," but amusing dialogue, great sight gags and a charismatic cast make the film work. Rosalee Futch (Kate Bosworth, "Blue Crush") and her best friend Cathy (Ginnifer Goodwin, "Mona Lisa Smile") both work as cashiers at a West Virginia Piggly Wiggly for their buddy Pete (Topher Grace, "Traffic," TV's "That 70's Show") who is shoring up the nerve to declare his long time love for Rosalee. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance". This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary". The cookie is used to store the user consent for the cookies in the category "Other. The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". ![]() The cookie is used to store the user consent for the cookies in the category "Analytics". These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly. ![]() Lambro Industries 4004 Quick Connect Flexible Aluminum Duct Dryer Vent Kit
![]() Once you’ve created a document in a text editor of your choice, you can easily convert the file into PDF with the click of a button. As such, CutePDF Writer works with all the Windows programs that support printing. The program doesn’t function like a standalone application but lists itself as a printer subsystem in the Device Manager. The interface is simple and allows seamless integration with Windows PCs. ![]() How does CutePDF Writer work?ĬutePDF Writer is quite different from leading software like Quick PDF Tools. The easy-to-use tool has a faster processing time than most competitors and doesn’t cause any lags or crashes. Since it doesn’t stress CPU performance, you can keep it running in the background. While programs like PDF Writer for Windows 10 can be heavy on system resources, CutePDF Writer is a lightweight application. 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The PDF viewer installs itself as a virtual printer, enabling a wide range of Windows apps to create high-quality PDF documents. It’s the free version of the more powerful commercial software. CutePDF Writer is a useful PDF reader, viewer, and converter, allowing you to create PDFs with ease. Whether you consider individual usage or business requirements, users around the world have been sharing data, content, and other information in the form of PDFs. Portable Document Format or PDF has been the standard for a reliable and secure exchange of digital files over the internet. While the free version of the program comes with limited features, it’s sufficient for basic usage and requirements. ![]() With Ghostscript-based tools like CutePDF Writer, it has been easier to read, write, and convert PDFs on Microsoft computers. Until a few years ago, it was quite difficult to create PDFs, and you had to rely on Adobe Reader DC and other free online PDF tools. 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